Effect of Hydrogen Sulfide on Ileum and Colon Motility in Experimental Model of Peritonitis in Rats

dc.contributor.author Tuncer, Evren
dc.contributor.author Yildirim, Sahin
dc.date.accessioned 2024-07-05T15:23:58Z
dc.date.available 2024-07-05T15:23:58Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [Tuncer, Evren] Atilim Univ, Dept Pharmacol, Fac Med, Ankara, Turkiye; [Yildirim, Sahin] Cumhuriyet Univ, Dept Pharmacol, Fac Med, Sivas, Turkiye en_US
dc.description.abstract Background and Objective: Studies investigating the association of H2S and nitric oxide signaling with intestinal motility in peritonitis are limited. The objective of this study was to explore how H2S influences the motility of the ileum and colon within an experimental peritonitis model. Materials and Methods: Three groups with 6 Wistar albino rats in each were used: Group 1 (Control), Group 2 (Peritonitis) and Group 3 (Sham). The experiment involved inducing contractions using either carbachol or electrical field stimulation (EFS) and relaxation responses are recorded upon the addition of L-cysteine, DL-PAG or NaHS, irrespective of whether L-NAME was added or not. Shapiro-Wilk Francia test, Levene test and Independent -Samples-t tests were used for the statistical analysis. Results: After induction with EFS or after pre-contraction with carbachol, relaxation rate (%) with NaHS was higher than relaxation rates (%) with L-cysteine and DL-PAG in the colon for all groups. The relaxation with NaHS was similar in all ileum groups after induction with EFS (p = 0.073), but in Group 2, responses were higher (p = 0.003 and p<0.001). The L-NAME did reveal a significant change in the presence of NaHS after precontraction either with carbachol or EFS in the colon for all groups (p<0.05). Conclusion: The NaHS induced significantly greater relaxation in the colon and it was more effective in the Peritonitis groups. The addition of L-NAME did result in a critical response with NaHS, after pre-contraction with carbachol in the colon Peritonitis group. The well-established fact is that a strong interplay exists between the NO and H2S signaling pathways. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.3923/ijp.2024.582.592
dc.identifier.endpage 592 en_US
dc.identifier.issn 1811-7775
dc.identifier.issn 1812-5700
dc.identifier.issue 4 en_US
dc.identifier.startpage 582 en_US
dc.identifier.uri https://doi.org/10.3923/ijp.2024.582.592
dc.identifier.uri https://hdl.handle.net/20.500.14411/2355
dc.identifier.volume 20 en_US
dc.identifier.wos WOS:001229830800006
dc.identifier.wosquality Q4
dc.institutionauthor Tuncer, Evren
dc.language.iso en en_US
dc.publisher Asian Network Scientific information-ansinet en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject H2S en_US
dc.subject colon en_US
dc.subject ileum en_US
dc.subject motility en_US
dc.subject relaxation en_US
dc.subject peritonitis en_US
dc.title Effect of Hydrogen Sulfide on Ileum and Colon Motility in Experimental Model of Peritonitis in Rats en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
relation.isAuthorOfPublication 22f88541-afe7-477d-b609-9be63be28e08
relation.isAuthorOfPublication.latestForDiscovery 22f88541-afe7-477d-b609-9be63be28e08

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