Perspectives on Molecular Mimicry Between Human, SARS-CoV-2, and Plasmodium Species Through a Probabilistic and Evolutionary Insight

Abstract

This chapter examines potential molecular mimicry between similar peptide sequences and shared 6mers of five selected proteins and the proteomes of both SARS-CoV-2 and five Plasmodium species that infect humans (P. falciparum, P. malariae, P. vivax, P. knowlesi, and P. ovale). Human proteins are plasminogen receptor (KT), neutrophil collagenase (neutrophil collagenase isoform 2), myeloperoxidase precursor, mitochondrial peptide methionine sulfoxide reductase isoform a precursor, and myeloblastin precursor. The chapter eventually focuses on a probabilistic and evolutionary insight into molecular mimicry. © 2024 Elsevier B.V. All rights reserved.