Does Esmolol Havean Effect on Erythrocyte Deformability in Rat Lower Limb İschemia Reperfusion İnjury?

Abstract

Following Ethics Commitee approval 24 rats were randomly divided into 4 groups, Control (Group C), Esmolol (Group E), Ischemia-reperfusion (Group I/R), I/R-Esmolol (Group I/R-E). In I/R group, atraumatic microvascular clamp was placed to infrarenal abdominal aorta. After 120 minutes from ischemia, the clamp was removed and reperfusion was performed for 120 minutes. Esmolol (200 μg/kg/min) was administered 30 minutes before the operation in I/R-Esmolol group. Erythrocytes were obtained from heparinized whole blood samples. A constant flow filtrometer was used to measure erythrocyte deformability and relative resistance was calculated.