The Evaluation of Oxidative Stress in the Young Adults With Covid-19 Mrna Vaccines Induced Acute Pericarditis- Myopericarditis

dc.authorid Dursun, Ali Dogan/0000-0001-9056-0025
dc.authorid Cantekin, Ömer Faruk/0000-0001-5096-3233
dc.authorscopusid 57196954194
dc.authorscopusid 15840456000
dc.authorscopusid 57223187926
dc.authorscopusid 56105521000
dc.authorscopusid 57428018900
dc.authorwosid Dursun, Ali Dogan/AAH-7617-2019
dc.authorwosid Cantekin, Ömer Faruk/AHE-6254-2022
dc.contributor.author Dursun, Ali Dogan
dc.contributor.author Saricam, Ersin
dc.contributor.author Sariyildiz, Gulcin Turkmen
dc.contributor.author Iscanli, Murat Dogan
dc.contributor.author Cantekin, Omer Faruk
dc.contributor.other Anesthesia Program
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:16:29Z
dc.date.available 2024-07-05T15:16:29Z
dc.date.issued 2022
dc.department Atılım University en_US
dc.department-temp [Dursun, Ali Dogan] Atilim Univ, Dept Physiol, Sch Med, Ankara, Turkey; [Dursun, Ali Dogan] Medicana Int Ankara Hosp, Check Up Ctr, Home Care Serv, Ankara, Turkey; [Saricam, Ersin] Medicana Int Ankara Hosp, Dept Cardiol, Ankara, Turkey; [Saricam, Ersin] Atilim Univ, Dept Cardiol, Sch Med, Ankara, Turkey; [Sariyildiz, Gulcin Turkmen] Medicana Int Ankara Hosp, Dept Gen Surg, Ankara, Turkey; [Sariyildiz, Gulcin Turkmen] Atilim Univ, Vocat Sch Hlth Serv, Operating Room Serv, Ankara, Turkey; [Iscanli, Murat Dogan] Medicana Int Ankara Hosp, Dept Emergency Med, Ankara, Turkey; [Iscanli, Murat Dogan] Atilim Univ, Dept Emergency Med, Sch Med, Ankara, Turkey; [Cantekin, Omer Faruk] Gazi Univ, Fac Hlth Sci, Dept Social Work, Ankara, Turkey en_US
dc.description Dursun, Ali Dogan/0000-0001-9056-0025; Cantekin, Ömer Faruk/0000-0001-5096-3233 en_US
dc.description.abstract Background: During COVID-19 pandemic, several vaccines have been developed such as mRNA vaccines. However, acute pericarditis and myocarditis/myopericarditis cases have been described after mRNA vaccination. The mechanism for the development of cardiac involvement is unknown. Potential mechanism for oxidative stress associated with vaccine-induced heart involvement is unidentified. This study aimed to examine the role of oxidative stress and the heart involvement in young adults vaccinated with COVID-19 mRNA vaccines. Methods: In this cross-sectional study, a total of 23 participants were included and 10 of these participants were asymptomatic patients (control group). Comparison of the cardiac involvement and control group was made by using troponin I, C-reactive protein (hsCRP), D-dimer levels, and oxidative stress tests including nitric oxide, and imaging techniques (ECG, echocardiography, cardiovascular magnetic resonance). Results: The median age of acute pericarditis group (10 patients) was 22 years (Q1-Q3: 18.5-31), and the mean age was 24.4 +/- 7.5 years. The median age of myopericarditis group (3 patients) was 22 years (Q1-Q3 18.0-25.0), and the mean age was 21.6 +/- 3.5 years. All the myopericarditis cases were male. The patients with myopericarditis had higher troponin I level, hsCRP, and D-dimer levels (troponin I level; 1600.00 ng/mL; D-dimer; 1.20 mu g/mL, hsCRP; 3.0 mg/L, respectively; p < 0.05). Serum nitric oxide levels and OSI (total oxidant status, H2O2/total antioxidant status) were lower in myopericarditis group than the control and acute pericarditis group (p < 0.05). This shows inflammatory and procoagulant state. Conclusion: Vaccine-induced myopericarditis cases are associated with oxidative stress test abnormality (abnormal NO, OSI levels). However, there is no relationship between NO levels and other oxidative stress tests difference in vaccine-induced acute pericarditis. It is thought that vaccine-induced pericarditis and myopericarditis could have different pathogenesis. This could make it necessary to reassess the second dose of vaccination for vaccine-induced cardiac involvement cases. en_US
dc.identifier.citationcount 6
dc.identifier.doi 10.2147/IJGM.S347977
dc.identifier.endpage 167 en_US
dc.identifier.issn 1178-7074
dc.identifier.pmid 35023954
dc.identifier.scopus 2-s2.0-85123528782
dc.identifier.startpage 161 en_US
dc.identifier.uri https://doi.org/10.2147/IJGM.S347977
dc.identifier.uri https://hdl.handle.net/20.500.14411/1643
dc.identifier.volume 15 en_US
dc.identifier.wos WOS:000742135800004
dc.institutionauthor Sarıçam, Ersin
dc.institutionauthor Sarıyıldız, Gülçin Türkmen
dc.institutionauthor Dursun, Ali Doğan
dc.institutionauthor İşcanlı, Murat Doğan
dc.language.iso en en_US
dc.publisher Dove Medical Press Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 10
dc.subject COVID-19 vaccine en_US
dc.subject cardiac involvement en_US
dc.subject oxidative stress en_US
dc.title The Evaluation of Oxidative Stress in the Young Adults With Covid-19 Mrna Vaccines Induced Acute Pericarditis- Myopericarditis en_US
dc.type Article en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication
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