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  • Article
    Development and In-Vitro Evaluation of Gallium-68 Labelled Staphylococcus Aureus-Specific Aptamer as a Potential PET Agent for Infection Imaging
    (IJRR-Iranian Journal Radiation Res, 2025) Bargh, S.; Ozkul, C.; Timur, S. S.; Ozalp, V. C.; Erdogan, S.
    Background: Staphylococcus aureus (S. aureus) is the most common causative pathogen associated with a wide range of infections, from mild to life-threatening conditions such as osteomyelitis, endocarditis, and pneumonia. Early detection and reliable differentiation between infection and sterile inflammation are essential for accurate diagnosis and effective treatment. However, most radiopharmaceuticals currently available fail to discriminate between these conditions, underscoring the need for infection-specific imaging agents. Materials and Methods: In this study, a Gallium-68 (Ga-68)-labeled S. aureus-specific aptamer was developed as a potential PET infection imaging probe. Aptamers were selected using the cell- systematic evolution of ligands by exponential enrichment (SELEX) method, and their specificity was verified by fluorescence-based binding assays. Radiolabeling was achieved via DOTA chelation, and radiochemical purity was determined. Additionally, in vitro binding assays were performed with S. aureus, while Escherichia coli (E. coli) served as a control. Results: The aptamer exhibited an affinity constant (K-a) of 2260 +/- 634 CFU/ mL and a linear detection range of 250-2x10(4) CFU/mL, with a limit of detection of 171 CFU/mL for S. aureus. The Ga-68-labeled aptamer demonstrated radiochemical purity greater than 99%. In vitro binding increased linearly with rising S. aureus concentrations (10(3)-2x10(4) CFU/mL), while minimal binding to E. coli confirmed its specificity. Conclusion: These results demonstrate that the Ga-68-labeled S. aureusspecific aptamer holds promise as an infection-targeted PET imaging agent. Although currently limited to in vitro evaluation, such aptamer-based radiopharmaceuticals may contribute to improved diagnosis and imaging of infectious diseases.
  • Article
    Investigation of Tetanus Seropositivity Levels in Adult Patients with Rabies Risk Exposure Admitted To a Hospital in Ankara
    (J Infection Developing Countries, 2025) Gurkaynak, Pinar; Demircan, Serife A.; Tulek, Necla; Kinikli, Sami; Erdinc, Fatma S.; Tuncer, Gunay
    Introduction: This study aimed to assess tetanus seropositivity levels among adult patients admitted to a tertiary care hospital following rabies risk exposure, and to explore potential factors influencing their immunological status. Methodology: This cross-sectional descriptive epidemiological study included 182 adult individuals (68 females and 114 males) who presented to the hospital following rabies risk exposure. The demographic data was collected during a face-to-face interview, and the tetanus antibody concentrations were assessed using a micro-enzyme-linked immunosorbent assay (ELISA) kit. Serum antibody levels of >= 0.1 IU/mL were defined as "seropositive", while values below this threshold were considered "seronegative". Results: Seropositivity was identified in 81.9% of the patients. There was a significant decline in antibody levels with age (p < 0.001). The Spearman correlation analysis showed a moderately significant negative correlation between age and antibody titers (r = - 0.404, p < 0.001). In addition, there were significantly higher tetanus antibody levels in patients from urban areas, those vaccinated during pregnancy, and those vaccinated within the past 10 years (p = 0.025, 0.036, and 0.013, respectively). Conclusions: Overall, the results highlight a reduction in tetanus antibody levels with age, emphasizing the importance of receiving a booster dose every 10 years. In addition, rabies risk exposure, particularly in older adults, presents a valuable opportunity to administer tetanus vaccination.
  • Article
    Türkiye’de Fizyoterapi ve Rehabilitasyon Alanında, Öğrenci, Akademisyen ve Klinisyen Bakış Açısıyla Kanıta Dayalı Uygulamanın Yeri: Pilot Çalışma
    (Turkey Assoc Physiotherapists, 2025) Akınoğlu, Bihter; Bengüboz, Fatma Büşra; Arıkan, Zeynep
    Amaç: Kanıta dayalı uygulama (KDU), yüksek kaliteli klinik araştırmalara ve uygulamalara dayanan bir yöntemdir. Dünya Fizyoterapi Konfederasyonu’na göre KDU eğitimi fizyoterapi uygulama önerilerinin başında gelmelidir. Çalışmamızın amacı Türkiye’de fizyoterapi ve rehabilitasyon alanında, öğrenci, akademisyen ve klinisyen bakış açısıyla KDU’nun yerini ve önündeki engelleri araştırmaktır. Yöntem: Çalışma pilot çalışma olarak planlanmıştır. Çalışma süresince ulaşılabilecek bütün fizyoterapi ve rehabilitasyon alanında olan öğrenci, akademisyen ve klinisyenler ile çalışma gerçekleştirilmiştir. Değerlendirmede 28 sorudan oluşan “KDU Ölçeği” ve çalışmacılar tarafından hazırlanan KDU konusundaki görüşler, bilgi seviyesi, önündeki engellerin sorgulandığı bir form kullanılmıştır. Çalışma verileri web tabanlı bir form oluşturularak toplanmıştır. Bulgular: Çalışmamız 44 öğrenci, 22 akademisyen ve 31 klinisyen olmak üzere toplam 97 kişi ile gerçekleştirilmiştir. KDU’yu engelleyen faktörler cevaplarında “Order (tedavide hekim talimatı) almak” öğrencilerde %51,06, akademisyenlerde ve %31,57 klinisyenlerde %33,33 oranla ilk engel olarak belirtilmiştir. KDU ölçeği toplam puanları üç grup arasında karşılaştırıldığında istatistiksel olarak anlamlı farklar olduğu tespit edilmiştir (p=0,000). Sonuç: Çalışmamızın sonuçlarına bakıldığında farklı alanlarda bulunan fizyoterapistlerin KDU bilgi ve tutumlarının farklılıklar gösterdiği fakat ortak olarak Türkiye’de fizyoterapi ve rehabilitasyon alanında, öğrencilerin, klinisyenlerin ve akademisyenlerin KDU zorlaştırıcılarının başında “Order almak” faktörünün olduğu görülmüştür.
  • Article
    Toxoplasma gondii Coinfection in HIV-Positive Patients at a Tertiary Care Hospital
    (Bentham Science Publ Ltd, 2025) Kurkcu, Muhammed Furkan; Bakir, Ayfer; Kaba, Semiha Berra Topsakal; Kusabbi, Ilknur Alkan; Usluca, Selma
    Introduction: Toxoplasma gondii (T. gondii) can cause serious complications in both immunocompetent and immunosuppressed individuals. This study aims to assess the seroprevalence of T. gondii among HIV-positive individuals and to investigate its association with age, sex, CD4+ T cell count, HIV RNA levels, and hematological parameters. Methods: This study included 247 HIV-positive individuals followed up at a tertiary care hospital between November 1, 2022, and November 30, 2024. We analyzed serum samples for T. gondii IgG antibodies using electrochemiluminescent microparticle immunoassay. Results: The prevalence of T. gondii IgG seropositivity was found to be 32.8% (n=81; 95% CI: 26.9-39). The median age of seropositive individuals was 52 years (IQR: 42-61), which was significantly higher compared to seronegative individuals (p<0.001). The highest IgG seropositivity rate (66.7%) was observed in the 61-80 age group. Hemoglobin levels were significantly lower in IgG seropositive individuals (p=0.040). Logistic regression analysis indicated an increased risk of T. gondii infection with advancing age. The odds ratio for the 41-60 age group was 13.3 (95% CI: 1.6-106, p=0.02), while for the 61-80 age group, it was 28 (95% CI: 3.3-240, p=0.002). Discussion: The seroprevalence of T. gondii in HIV-positive individuals was lower than both global and regional averages. Age was identified as an independent risk factor for T. gondii seropositivity. Additionally, hematological alterations associated with anemia were observed in seropositive individuals. Further large-scale, multi-center, and regionally representative studies are required to optimize T. gondii infection management and screening strategies in people living with HIV. Conclusion: These findings suggest that T. gondii infection in HIV-positive individuals increases with age and may be associated with anemia, highlighting the need for age-focused screening and management strategies.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Physics-Informed Neural Network for Nonlinear Bending Analysis of Nano-Beams: A Systematic Hyperparameter Optimization
    (MDPI, 2025) Esfahani, Saba Sadat Mirsadeghi; Fallah, Ali; Aghdam, Mohammad Mohammadi; Mohammadi Aghdam, Mohammad; Mirsadeghi Esfahani, Saba Sadat
    This paper investigates the nonlinear bending analysis of nano-beams using the physics-informed neural network (PINN) method. The nonlinear governing equations for the bending of size-dependent nano-beams are derived from Hamilton's principle, incorporating nonlocal strain gradient theory, and based on Euler-Bernoulli beam theory. In the PINN method, the solution is approximated by a deep neural network, with network parameters determined by minimizing a loss function that consists of the governing equation and boundary conditions. Despite numerous reports demonstrating the applicability of the PINN method for solving various engineering problems, tuning the network hyperparameters remains challenging. In this study, a systematic approach is employed to fine-tune the hyperparameters using hyperparameter optimization (HPO) via Gaussian process-based Bayesian optimization. Comparison of the PINN results with available reference solutions shows that the PINN, with the optimized parameters, produces results with high accuracy. Finally, the impacts of boundary conditions, different loads, and the influence of nonlocal strain gradient parameters on the bending behavior of nano-beams are investigated.
  • Conference Object
    Short-Term Gains, Long-Term Gaps: The Impact of GenAI and Search Technologies on Retention
    (Springer International Publishing AG, 2025) Akgun, Mahir; Toker, Sacip
    The rise of Generative AI (GenAI) tools, such as ChatGPT, has transformed how students access and engage with information, raising questions about their impact on learning outcomes and retention. This study investigates how GenAI (ChatGPT), search engines (Google), and e-textbooks influence student performance across tasks of varying cognitive complexity, based on Bloom's Taxonomy. Using a sample of 123 students, we examined performance in three tasks: [1] knowing and understanding, [2] applying, and [3] synthesizing, evaluating, and creating. Results indicate that ChatGPT and Google groups outperformed the control group in immediate assessments for lower-order cognitive tasks, benefiting from quick access to structured information. However, their advantage diminished over time, with retention test scores aligning with those of the e-textbook group. For higher-order cognitive tasks, no significant differences were observed among groups, with the control group demonstrating the highest retention. These findings suggest that while AI-driven tools facilitate immediate performance, they do not inherently reinforce long-term retention unless supported by structured learning strategies. The study highlights the need for balanced technology integration in education, ensuring that AI tools are paired with pedagogical approaches that promote deep cognitive engagement and knowledge retention.
  • Article
    The Effect of Endurance-Based Sports on Athlete Success and Psychological Well-Being
    (Campus Educa Sports Sl, 2025) Ozpinar, Saliha; Yucel, Ali Serdar; Korkmaz, Murat; Oztas, Dilek; Kuyucu, Mihalis Michael; Aras, Goksen; Yüce, Ali Serdar
    The aim of this study is to examine the effects of psychological resilience on sport success and mental health. The relationships between commitment, control and challenge, which are sub-dimensions of psychological resilience, and sport success and psychological wellbeing were evaluated and discussed in detail. Today, the problems arising due to the increasing competitive environment and stress factors have made it more important for athletes to be psychologically strong. Although the relationship between psychological resilience and sport success has been previously examined in the literature, studies evaluating the individual effects of the sub-dimensions of resilience in a large sample group are quite limited. This study aims to overcome this deficiency and make an up-to-date contribution to the subject. A total of 684 students (72 percent male, 28 percent female) studying at the Faculties of Sport Sciences of 16 universities in Istanbul, Ankara, Izmir, Bursa and Antalya participated in the study. Participants completed the Resilience Scale and Mental Health Inventory, and their sporting achievements were evaluated by their coaches using the Sport Achievement Scale. Data were collected via Google Forms (R) and analysed using SPSS 22.0 software with correlation, regression and Granger causality tests. The findings revealed that all resilience sub-dimensions showed positive and significant relationships with sport achievement ( R-2=0.93) and psychological well-being (R-2=0.68). Especially control and challenge factors had the strongest effects. As a result of the research, commitment, control and challenge, which are the sub-dimensions of psychological resilience, significantly affect both success levels and psychological well-being of athletes. Therefore, resilience development programmes for athletes should focus on these areas.
  • Article
    Reflection of 20th-Century Techno-Utopias To the Present Day: Capsule Hotels
    (Nilay Ozsavas Ulucay, 2025) Kose, Merve; Memikoglu, Ipek
    Several factors, such as population growth, increasing land prices, and challenging economic conditions, have led to a change in hotel design. In response to these challenges, capsule hotels have emerged as a potential solution. These hotels are designed to be compact, cost-effective, and conveniently located near airports or train stations. Inspired by the 20th-century techno-utopias and first emerging in Japan during the 1970s, these capsule hotels have spread to many countries in the 21st-century. The aim of this study is to identify the common and distinctive features of capsule hotels in different countries. Three capsule hotel examples were selected, namely the Nine Hours Capsule Hotel in Osaka, the KINN Capsule Hotel in Singapore, and the Capsule Hotel-Sydney in Sydney. The study used a mixed qualitative research method, including conceptual analysis and case study, and the selected hotel examples were analyzed using the homogeneous sampling technique. The design of these hotels, characterized by economic efficiency and limited facilities, shows variations across different countries in terms of capsule dimensions, color schemes, materials, and furnishings. The findings reveal discrepancies in location, color schemes, material choices, and amenities; however, the size, configuration, and access orientations of the capsules remain consistent with the established capsule hotel concept as defined in the literature.
  • Article
    The Effect of Instant Stimulation To Kidney 3 Acupuncture Point on DPOAE Responses in Patients With Tinnitus
    (Sage Publications inc, 2025) Arslan, Berkay; Tuncer, Sebahattin
    Introduction Tinnitus is the perception of sound in the ear or brain in the absence of any external stimulation. Theories regarding tinnitus pathology often involve both cochlear involvement and central regions. Different and alternative medical treatment options have been widely used to help individuals suffering from tinnitus. Objective This study aims to investigate the effect of instant stimulation to the Kidney 3 (KI3) acupuncture point on distortion product otoacoustic emissions (DPOAE) in patients with tinnitus. Material and Method Thirty patients (21 male, 9 female) with subjective tinnitus and normal hearing were included in the study. A total of 39 ears (22 left ears, 17 right ears) were evaluated. After audiological evaluations, the effects of instantaneous stimulation of the bilateral KI3 acupuncture point on DPOAE at frequencies ranging from 1,000 to 6,000 Hz were measured. Results There was a significant difference between amplitudes before and during acupuncture application at all tested frequencies, except at 4,000 Hz in patients with tinnitus in the right ear. There was also a significant difference between amplitudes of before and after acupuncture application at 3,000 and 4,000 Hz in patients with tinnitus in the left ear. Lower amplitude was observed at these frequencies compared with before the application. In patients with bilateral tinnitus, there was a significant amplitude difference between before and during application at 1,000, 2,000, and 3,000 Hz frequencies for the left ear. Conclusion Instant stimulation to the KI3 acupuncture point changed DPOAE amplitude values in patients with tinnitus.